A13 TG2-CATALYZED TRANSAMIDATION OF K3 AND Q102 RESIDUES TRANSFORMS LATENT S100A11 CALGRANULIN INTO AN INDUCER OF MATRIX CATABOLISM AND HYPERTROPHIC DIFFERENTIATIONIN CHONDROCYTES
نویسندگان
چکیده
منابع مشابه
Transamidation by transglutaminase 2 transforms S100A11 calgranulin into a procatabolic cytokine for chondrocytes.
In osteoarthritis (OA), low-grade joint inflammation promotes altered chondrocyte differentiation and cartilage catabolism. S100/calgranulins share conserved calcium-binding EF-hand domains, associate noncovalently as homodimers and heterodimers, and are secreted and bind receptor for advanced glycation end products (RAGE). Chondrocyte RAGE expression and S100A11 release are stimulated by IL-1b...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2006
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(07)60466-x